姓  名:
李健
职  称:
研究员 博导
研究领域:
人类强化学习和决策的神经机制
联系电话:
+86 10 62767123(O)
通信地址:
北京大学王克桢楼 100080
电子邮件:
li.jian@pku.edu.cn

李。,现为北京大学心理与认知科学彩5vip下载研究员。回国前于纽约大学心理系任职研究科学家。2000年由南京大学获得理学学士学位,2005年获得2007年贝勒医彩5vip下载获得神经生物学博士学位,学习期间获得全额奖学金, 2010年获得纽约大学斯特恩 (Stern) 商彩5vip下载工商管理学硕士 (MBA) 学位。李健博士于 2005年获得 John Merck Foundation赞助的在普林斯顿大学的“旅行基金”,同年获得布朗基金 (Brown Foundation) 奖学金,2006年获得国家教育部颁发的“海外自费留学生奖学金”,2011年获得国际神经生物学协会和格鲁博基金会 (Gruber Foundation) 颁发的“格鲁博国际神经生物学研究奖”,同年获得美国国家药物成瘾研究所(NIDA)的“研究旅行基金”, 2014年获得求是基金会“杰出青年学者奖”。

李健博士现担任Cognitive, Affective & Behavioral Neuroscience, European Journal of Neuroscience, NeuroImage, Journal of Cognitive Neuroscience, NeuroComputing, Neuropsychopharmacology, Proceedings of National Science, The Anatomical Record, Neural Computation, PLoS ONE 杂志的审稿人。

李健博士的研究主要集中于人类与奖赏信息相关的学习和对应决策的认知神经机制的研究。其早期的工作证明了纹状体作为多巴胺神经元的主要投射区域在以获得奖赏最大化的情境中所承担的具体功能,纹状体的活动和被试动态调整决策实现利益最大化的过程呈显著的相关。李健博士的工作扩展了多巴胺奖赏通路的适用范围,即多巴胺环路和其具体的计算功能不仅仅局限于初级(如食物,水,性活动)和次级(如金钱)强化物,同样的机理同样适用于其他模态的强化物(如婴儿的微笑,社会其他群体的信任,艺术品的美感等)。提供了有力的证据支持不同模态的奖赏信息都与大脑多巴胺环路活动关系密切;个体对于这些多模态奖赏信息的过度依赖甚至成瘾和多巴胺环路活动的紊乱有直接的联系。李健博士近年来的工作集中于理解大脑其他参与彩5vip下载奖赏学习和决策的脑区如何和纹状体协同作用提高学习效率。同时,他也关注社会信息如何干预和影响大脑中奖赏/多巴胺通路的活动从而影响个体的价值决策;这些工作对如何设计有效的干预手段调节人脑对于强化学习的依赖程度提供了具体的理论指导和实验数据支撑。

现主持的科研项目有:

国家自然科学基金委员会优秀青年科学基金:认知学习与价值决策

面上项目:不确定环境下强化学习和决策的神经机制

科技部“青年973项目”:模型驱动的奖赏记忆相关脑区的功能整合研究

基金协作项目:非常规突发事件应急管理基础科学问题与“情景-应对”型总集成生化平台研究

基金创新群体(协作项目):高级认知的神经和分子遗传机理

英文论著

McClure, S.M.*, Li, J.*, Tomlin, D., Cypert, K.S., Montague, L.M. and Montague, P.R. (2004) Neural Correlates of Behavioral Preference for Culturally Familiar Drinks. Neuron, 44: 379-87.

Li, J.*, McClure, S.M.*, King-Casas, B. and Montague, P.R. (2006) Policy Adjustment in a Dynamic Economic Game. PLoS ONE 1(1): e103. *Authors contributed equally to the work.

Bogacz, R., McClure, S.M., Li, J., Cohen, J.D. and Montague, P.R. (2007) Short-term Memory Traces for Action Bias in Human Reinforcement Learning. Brain Research, 1153: 111-21.

Strathearn, L., Li, J., Fonagy, P. and Montague, P.R. (2008) What’s in a Smile? Maternal Brain Responses to Infant Facial Cues. Pediatrics, 122(1): 40-51.

Delgado, M.R., Li, J., Schiller, D. and Phelps, E.A. (2008) The Role of Striatum in Aversive Learning and Aversive Prediction Errors. Philosophical Transactions of The Royal Society B, 363(1511): 3787-3800.

Van den Bos, W., Li, J., Lau, T., Maskin, E., Cohen, J.D., Montague, P.R. and McClure, S.M. (2008) The Value of Victory: Social Origins of the Winner’s Curse in Common Value Auctions. Judgment and Decision Making 3: 483-492.

Li, J., Xiao, E., Houser, D. and Montague, P.R. (2009) Neural Response to Sanction Threats in Two- Party Economic Exchange. PNAS 106:16835-16840.

Dickerson, K.C., Li, J., Delgado, M.R. (2011) Parallel Contributions of Distinct Human Memory Systems During Probabilistic Learning. NeuroImage 55(1): 266-276.

Li, J., Delgado, M.R., Phelps, E.A. (2011) How Instructed Knowledge Modulates the Neural Systems of Reward Learning. PNAS 108(1): 55-60.

Li, J., Daw, D. (2011) Signals in Human Striatum are appropriate for Policy Update Rather Than Value Prediction. Journal of Neuroscience 31(14): 5504-5511.

Li, J., Schiller, D., Schoenbaum, G., Phelps, E.A. and Daw, D. (2011) Differential Roles of Human Striatum and Amygdala in Associative Learning. Nature Neuroscience 14(10): 1250-1252.

Jones, R.M., Somerville, L.H., Li, J., and Casey, B.J. (2011) Behavioral and Neural Properties of Social Reinforcement Learning. Journal of Neuroscience 31(37): 13039-13045.

Roesch, M.R., Esber, G.R., Li, J., Daw, N.D. and Schoenbaum, G. (2012) Surprise! Neural Correlates Linking Pearce-Hall and Rescorla-Wagner. European Journal of Neuroscience 35: 1190-1200.

Kishida, K.T., Li, J., Schwind, J. and Montague, P.R. (2012) New Approaches to Investigating Social Gestures in Autism Spectrum Disorder. Journal of Neurodevelopmental disorders 4-14.

Sip, K.E., Carmel, D., Marchant, J.L., Li, J., Petrovic, P., Roepstorff, A., McGregor, W.B. and Frith, C.D. (2013) When Pinocchio’s Nose does not Grow: Belief Regarding Lie-detectability Modulates Production of Deception. Frontiers in Human Neuroscience 7:16. Doi: 10.3389/fnhum.2013.00016. Epub 2013 Feb 4.

Kubota, J.T., Li, J., Bar-David, E., Banaji, M.R. and Phelps, E.A. (2013) The Price of Racial Bias: Intergroup Negotiations in the Ultimatum Game. Psychological Science 24(12): 2498-2504.

Jones, R.M., Somerville, L.H., Li, J., Ruberry, E.J., Powers, A., Mehta, N., Dyke, J., Casey, B.J. (2014) Adolescent-specific patterns of behavior and neural activity during social reinforcement learning. Cognitive, Affective, & Behavioral Neuroscience 14(2): 683-97.

Kubota, J.T., Li, J., Bar-David, E., Banaji, M.R. and Phelps, E.A. (2015) All claims in the original article hold as stated: a response to arkes. Psychological Science 26(2): 246-8.